đť—Łđť——đť—™ | On May 12, , Dr Sumanta Mondal and others published UNIT-I: General Pharmacology. General pharmacology. Introduction of General pharmacology., . Lecturer. PHLPHARMACOLOGY AND THERAPEUTICS-I. General Pharmacology. Basic Principles. What is the nature of the drugs? The drug is a molecule that is able to change the function of an organism. Thus it .

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In general, this draft guidance focuses on the clinical pharmacology . /Drugs/ GuidanceComplianceRegulatoryInformation/Guidances/ucmpdf. l1: introduction to pharmacology pharmacology pharma drug logos study “study of drugs” drug any substance received by biological system, other than for. Basic Pharmacology. Drugs. Page 2. Pharmacology. ▫ Basic Principles. ○ Study of drugs Pharmacology. ▫ Directly linked to the pathophysiology of a.

On enquiry she revealed that she felt epigastric distress after vtaking the level was unchanged.

On enquiry she revealed that she felt epigastric distress after taking the iron capsules, and had started taking antacid tablets along with the capsules. What could be the possible reason for her failure to respond to the oral iron medication? A 50 year old man with type 2 diabetes was maintained on tab. Glibenclamide 5 mg twice daily.

He developed toothache for which he took tab. Aspirin mg 6 hrly. After taking aspirin he experienced anxiety, sweating, palpitation, weakness, ataxia, and was behaving abnormally.

These symptoms subsided when he was given a glass of glucose solution. Solved answers 9.

Gastric acid is required for the absorption of oral iron salts. Concurrent ingestion of antacid tablets could have interfered with iron absorption.

Hence, the anaemia failed to improve.

Therefore, plasma concentration of unbound and active glibenclamide would have risen after aspirin ingestion causing hypoglycemia which produced the symptoms. As such, glucose ingestion relieved the symptoms. As such, these analgesics are more suitable for the given patient. D Elimination of Drugs A 30 year old mother of 2 children weighing 60 kg was taking combined oral contraceptive pill containing levonorgestrel 0.

She developed fever with cough and was diagnosed as a case of pulmonary tuberculosis after sputum smear examination. In the 3rd month she failed to have the usual withdrawal bleeding during the gap period of contraceptive cycle.

After 10 days her urinary pregnancy test was found to be positive. The pharmacokinetic parameters and therapeutic plasma concentration of the selected drug are : Table:1 Abbildung in dieser Leseprobe nicht enthalten What should be the loading dose and the daily maintenance dose of the drug for this patient? Answers As such, fertility was restored and the women conceived. The total volume of distribution Vd should be calculated first. The maintenance dose may be one mg tab.

A patient being treated with methotrexate developed oral ulceration, megaloblastic anaemia and other toxic symptoms.

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A 65 year old male hepatic cirrhosis patient was admitted to the hospital for treatment of gross ascetic fluid.

He responded with brisk dieresis, but on the 3rd day he was found to be talking irrelevant, was weak and partly disoriented.

He had a fainting episode on getting up from the bed. Answers 1. However, because the binding affinity of Mtx for the enzyme is 50, times greater, even excess DHFA will not be able to displace it from the enzyme and non equilibrium type of inhibition will be produced.

Principles in General Pharmacology

On the other hand, folinic acid will supply readymade active coenzyme THFA and will be able to overcome Mtx toxicity. You can change your ad preferences anytime. General pharmacology. Upcoming SlideShare. Like this presentation?

Benzodiazepine Pharmacology and Central Nervous System–Mediated Effects

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No notes for slide. General pharmacology 1. Introduction 2. Pharmacokinetic 3. Pharmacodynamic 4. Drug 5. Various physiochemical properties the of drugs 6. Drug receptor interaction 7. Routes of administration 8. Conclusion 9.

References 2 3. It is the science of drugs as it deals with the interaction of exogenously administered chemical molecule Drug with living system. Oswald Schmiedeberg. Two main division of pharmacology are: It is the quantitative study of drug movement in, through and out of the body.

Schematically process of pharmacokinetic: Transportation Absorption Distribution- storage receptor metabolism free drug binding: Effect excretion. Drugs are transported across the membrane by: Passive diffusion and filtration. Facilitated diffusion. Active transport. Absorption is movement of the drug from its site of administration in to the circulation.

Ph influence f. Route of administration 7 8. It is the fraction of the drug that reaches to systemic circulation from a given dose in unchanged from in an unchanged form. The term bioavailability is generally used for drugs given through oral route. Two formulation of the same drug having equal bioavailability.


Once a drug has gained access to the blood stream, it gets distributed to other tissue that initially had no drug , concentration gradient being in the direction of plasma to tissue. Factor affecting drug distribution: First pass metabolism. Movement of the drug proceed until an equilibrium is established between unbound drug in plasma and tissue fluids. It means chemical alteration of the drug in the body.

Primary sites of drug metabolism is liver , others are — kidney, intestine lungs and plasma.May Learn how and when to remove this template message A variety of topics involved with pharmacology, including neuropharmacology , renal pharmacology, human metabolism , intracellular metabolism, and intracellular regulation The mechanism of action of beta blockers.

Conclusion 9. Pharmacodynamic 4. Gastrointestinal tract GIT. Systems pharmacology or network pharmacology is the application of systems biology principles in the field of pharmacology.

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